Matthias Barone

Postdoc

I studied Nanosciences at the University of Basel, an interdisciplinary curriculum that focuses on the interfaces between physics, biology, and chemistry. Due to that broad knowledge in biochemistry and physics, I developed great interest in protein crystallography and did my master thesis in the pharmaceutical industry investigating an antimalarial drug target. I pursued working in structure-guided drug design but moved towards cancer research for the doctoral thesis, which I graduated with summa cum laude at the Free University in Berlin. During the first years as postdoc, my interest then slowly shifted from crystallography and NMR to cellular data analysis, which I performed primarily with scripts written in R language.

Since April 2021 I am working as bioinformatician in the Sawitzki lab, where I establish the multiplex analysis workflow, such as imaging mass cytometry or PhenoCycler-Fusion and guide students through their projects. See the resources page for more information.

Projects of

Matthias

Barone

  • Cellular communication niches in cancer

  • Immune–metabolic signalling in bone repair

Publications of

Matthias

Barone

  • The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8+ T cells

    EMBO Reports

  • Complement activation induces excessive T cell cytotoxicity in severe COVID-19.

    Cell

Sawitzki Lab

Berlin Institute of Health at Charité (BIH) 
Center of Immunomics/Translational Immunology

Luisenstraße 65 
D-10117 Berlin