PROJECT DESCRIPTION
Acute viral infections such as SARS-CoV-2 or EBV can lead to persistent disease states characterized by fatigue, post-exertional malaise, cognitive impairment, and hypersensitivity to sensory stimuli. Severe forms of these conditions are diagnosed as myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). Despite their major impact on patients’ lives, diagnostic biomarkers and effective therapies remain lacking.
Our research aims to uncover the immune mechanisms underlying post-infectious syndromes and to enable biomarker-guided patient stratification for emerging therapies.
As part of the German National Clinical Study Group (NKSG) and the Netzwerk Universitätsmedizin Specialty Network Infectious Diseases (NUM-SNID), we contribute to national initiatives for a better understanding and treatment of post-infectious diseases (“National Decade against Post-Infectious Diseases”). We integrate high-dimensional immune profiling, multimodal single-cell analyses, and functional perturbation studies to identify disease-associated immune signatures and therapeutic targets.
Involved People
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Lucas Arendholz
Postdoc
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Dzenis Koca
Postdoc
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Karsten Jürchott
Postdoc
Related Publications
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Randomized adaptive assessment of post COVID syndrome treatments (RAPID): a study protocol for a multicenter, randomized, controlled adaptive platform trial of treatment options for Post Covid Syndrome (PCS) on patients physical function including the first intervention specific appendix RAPID_REVIVE (reducing inflammatory activity in patients with PCS).
Trials
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Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center.
Autoimmun Rev
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Haunting innate immune memories of COVID-19.
Cell
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Fighting Post-COVID and ME/CFS – development of curative therapies.
Front Med (Lausanne)