Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE

Cell

2020 Sep

182(6):1419-1440.e23

S0092-8674(20)30992-2 [pii], 10.1016/j.cell.2020.08.001 [doi]. PMID: 32810438

Link to Publication

Newest Publications

  • Mild hypothermia provides Treg stability

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies

  • Short-term cytokine stimulation reveals regulatory T cells with down-regulated Foxp3 expression in human peripheral blood

  • Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

  • CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures

  • TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

  • BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study

  • Gravitational stress during parabolic flights reduces the number of circulating innate and adaptive leukocyte subsets in human blood

  • A standardized immune phenotyping and automated data analysis platform for multicenter biomarker studies

  • The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8+ T cells

Sawitzki Lab

Berlin Institute of Health at Charité (BIH) 
Center of Immunomics/Translational Immunology

Luisenstraße 65 
D-10117 Berlin

© 2026